解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
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产科医学和妇科医学
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基本医疗保健
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健康政策和服务
心理学,临床
abstract::An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364767
更新日期:1984-01-01 00:00:00
abstract::Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345403
更新日期:1984-01-01 00:00:00
abstract::We examined the expression of H-Y antigen in 14 XO female mice using three monoclonal H-Y-specific antibodies. We found that spleen and liver cells from XO mice removed the reactivity of these antibodies at the same efficacy as XY cells. However radiobinding assays on cultured XO cells suggested a qualitative or quant...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00401354
更新日期:1983-01-01 00:00:00
abstract::The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345970
更新日期:1983-01-01 00:00:00
abstract::We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity desi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372458
更新日期:1983-01-01 00:00:00
abstract::We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372471
更新日期:1983-01-01 00:00:00
abstract::Kinetics and family transmission of antigen-specific in vitro cell-mediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6- to 7-day lymphocyte cultures. The ef...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372467
更新日期:1983-01-01 00:00:00
abstract::The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345969
更新日期:1983-01-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::The T- and B-cell surface polypeptides detected by an international workshop panel of 100 mouse monoclonal antibodies (M.Ab) were biochemically defined by radioimmunoprecipitation. Eight T-cell-associated molecules and eight B-cell-associated molecules were identified by multiple antibodies in the panel. Clusters of a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345968
更新日期:1983-01-01 00:00:00
abstract::The membrane immunoglobulin M (mIgM) of a B lymphocyte serves as a receptor for its cognate antigen. Our aim is to elucidate the structure and function of this membrane-bound receptor. The first step is to determine the requirements for proper membrane placement of IgM. We have used mIgM-positive B lymphocyte tumors f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364758
更新日期:1983-01-01 00:00:00
abstract::Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00952959
更新日期:1983-01-01 00:00:00
abstract::The H-2K glycoprotein from the MHC mutant bm10 was analyzed biochemically to determine where primary structural differences distinguished it from the parental standard molecule, Kb. Comparative peptide maps showed differences in two peptides known to be part of the parental CNBr fragment spanning amino acids 139 to 22...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364285
更新日期:1983-01-01 00:00:00
abstract::Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364333
更新日期:1982-03-01 00:00:00
abstract::A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372098
更新日期:1982-01-01 00:00:00
abstract::The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00621950
更新日期:1982-01-01 00:00:00
abstract::Immunoprecipitation of NP-40 lysates of 125I-labeled lymph-node cells with different anti-H-2 sera and with anti-Qa-2 serum has shown that the BALB/cByA strain (H-2d, Qa-2-negative) expresses, besides H-2Ld, another molecule that is not detectable in the BALB/c-H-2dm2 strain. Electrophoresis in SDS polyacrylamide gels...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345905
更新日期:1982-01-01 00:00:00
abstract::The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00343312
更新日期:1982-01-01 00:00:00
abstract::The role of H-2- and T-region products in determining allogeneic cell rejection was evaluated in H-2 congenic and recombinant mice by transplanting A1ATH and A6ATL leukemia cell lines induced in A.TH and A.TL strains, respectively, by Moloney murine leukemia virus.--In K- or D-region incompatible hosts transplant fail...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561686
更新日期:1981-03-01 00:00:00
abstract::A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561695
更新日期:1981-03-01 00:00:00
abstract::Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561675
更新日期:1981-01-01 00:00:00
abstract::Individual mice were tested for their proliferation T-cell response to H-Y- and H-3-incompatible stimulator cells in secondary mixed lymphocyte culture. Responders expressing the H-2b haplotype were restricted in their response to stimulators presenting H-Y and H-3 in the context of H-2b. Lymphocytes from individual B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00342193
更新日期:1981-01-01 00:00:00
abstract::Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364495
更新日期:1981-01-01 00:00:00
abstract::Direct immunoprecipitation and two-dimensional (2D) gel electrophoresis have been used to identify and characterize genetic variation of the H-2K and H-2D regions. Using inbred strains of mice and alloantisera, haplotype-specific polypeptides were defined for five different H-2 haplotypes. Specific immunoprecipitates ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561657
更新日期:1981-01-01 00:00:00
abstract::Two new C57BL/6 H-2 mutants, B6.C-H-2bm13 and B6.C-H-2bm14 are described. They arose independently in C57BL/6 as spontaneous mutations of the gain and loss type. Complementation studies map the mutations in both bm13 and bm14 to the H-2Db gene. However, these two mutant strains are not identical, but occurred as indep...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567801
更新日期:1980-01-01 00:00:00
abstract::In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567795
更新日期:1980-01-01 00:00:00
abstract::Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561562
更新日期:1980-01-01 00:00:00
abstract::Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561564
更新日期:1980-01-01 00:00:00
abstract::We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567793
更新日期:1980-01-01 00:00:00
abstract::An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567824
更新日期:1980-01-01 00:00:00
abstract::Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567827
更新日期:1980-01-01 00:00:00
abstract::Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngene...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561588
更新日期:1980-01-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00
abstract::Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01844036
更新日期:1978-12-01 00:00:00
abstract::The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01843991
更新日期:1978-12-01 00:00:00
abstract::An analysis of mRNA structures as deduced from the amino acid sequences of immunoglobulin heavy chains reveals possible base-paired regions within the sequences coding for the 20 C-terminal amino acids of the human μ and α chains. The two regions are similar in structure and contain a palindrome which might serve as a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01843981
更新日期:1978-12-01 00:00:00